Mounjaro

Mounjaro

Available in 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg

Get Mounjaro online from The Ravenor Pharmacy 

Mounjaro is an innovative injectable medication for weight management, featuring tirzepatide to mimic hormones that control appetite and blood sugar. Designed for adults with obesity or weight-related issues, it helps reduce hunger and enhance fullness with smaller meals. Combined with a healthy diet and exercise, Mounjaro supports effective and sustainable weight loss while improving overall health.

Why choose The Ravenor Pharmacy?

  • Comprehensive aftersales support to help you feel confident using Mounjaro.
  • GPhC and MHRA-registered pharmacy, backed by UK-based clinicians.
  • Fast 24-hour delivery, no GP or pharmacy visit required.

Mounjaro FAQs

Mounjaro is a pioneering weight loss injection, part of the latest generation of GLP-1 receptor agonists, specifically designed for individuals with a body mass index (BMI) over 30. Its active ingredient, tirzepatide, is central to Mounjaro’s effectiveness, offering a scientifically proven method to support weight loss.

Mounjaro works by mimicking hormones that target brain areas responsible for appetite regulation. Administered as a once-weekly injection under the skin, Mounjaro significantly reduces food cravings and enhances feelings of fullness. Clinical trials have shown that Mounjaro can help individuals achieve an impressive ~20% reduction in body weight, positioning it as a highly effective solution for weight management.

This advanced treatment is accessible through our UK-registered online prescribing service, offering a secure and convenient way to start your weight loss journey. After a simple online assessment with our clinical team, eligible individuals can receive their prescriptions processed and delivered within 24 hours. Our dedicated pharmacy team ensures the treatment is carefully prepared and dispatched directly to you, enabling a smooth transition toward a healthier lifestyle.

The Science Behind Mounjaro

Mounjaro, containing tirzepatide, is a once-weekly injectable that targets two important receptors involved in metabolic regulation: the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors.

Dual Receptor Agonism: A Two-Pronged Approach

Tirzepatide’s dual action is key to its effectiveness. By activating both the GIP and GLP-1 receptors, it helps regulate appetite and energy balance. The GIP receptor influences food intake and energy expenditure, while the GLP-1 receptor plays a role in insulin secretion and appetite control, providing a more comprehensive approach to weight management.

Clinical Trials and Efficacy

The SURMOUNT-1 trial and others have shown that Mounjaro is effective for weight loss, even in individuals without diabetes but who are overweight or obese. These trials confirmed the treatment’s weight-loss potential and safety profile, making it a promising option for those eligible.

Molecular Mechanisms at Play

Tirzepatide targets both the GIP and GLP-1 receptors, enhancing weight loss beyond what is achieved through GLP-1 activation alone. The GIP action improves energy balance and targets fat storage, while the GLP-1 receptor helps regulate appetite, making Mounjaro a powerful tool for weight management.

The full impact of Mounjaro, especially for weight management, may take several weeks to become apparent. This gradual effect is due in part to the methodical increase in dosage over time, designed to minimize potential side effects.

Research highlights the significant weight loss potential of Mounjaro, with those on the highest dose of 15mg experiencing impressive reductions, with some losing up to 22.5% of their initial body weight. Optimal results are best achieved when Mounjaro is combined with a healthy lifestyle, including a balanced diet, limited snacking, and consistent exercise, ideally reaching 150 minutes per week.

This effectiveness is supported by robust clinical trials. A phase 3 multicenter, double-blind, randomized, placebo-controlled study across 119 sites in nine countries demonstrated Mounjaro’s superior results compared to a placebo. Over a 72-week treatment period, participants on tirzepatide lost 15.0%, 19.5%, and 20.9% of their body weight with 5mg, 10mg, and 15mg doses, respectively, compared to a 3.1% loss with a placebo.

Additionally, the study showed that Mounjaro offers health benefits beyond weight loss. Participants experienced improvements in waist circumference, blood pressure, fasting insulin levels, and lipid profiles, suggesting its potential to reduce risks associated with cardiovascular diseases and metabolic disorders.

As for safety, while most participants experienced at least one adverse event, these were mostly gastrointestinal, mild to moderate, and occurred primarily during the dose-escalation phase. This suggests that while Mounjaro is highly effective in promoting weight loss and improving metabolic health, it also has a manageable safety profile.

Unlock the benefits of tirzepatide, a groundbreaking solution that helps manage appetite and regulate glucose levels, all from the comfort of your own home. Rely on The Ravenor Pharmacy to guide you on your journey to a healthier weight with Mounjaro, a revolutionary approach to overcoming obesity and weight-related challenges. Start your wellness journey today.

Research indicates that a single dose of tirzepatide can reduce the effectiveness of oral contraceptives. Specifically, it lowers the peak concentration (Cmax) and overall exposure (AUC) of the hormones in birth control pills.

To ensure continued contraceptive effectiveness, it is advised to use a barrier method, like condoms, or consider alternative contraceptive options that do not involve oral administration. This precaution should be followed for 4 weeks when starting Mounjaro treatment and for 4 weeks after any dose adjustments.

Mounjaro® Dosage and Administration Overview Mounjaro® is available in various dosages: 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg, each in a pre-filled pen. Always refer to the instructions for use and package leaflet for the latest guidance.

Dosage and Administration:
  • Initial Dose: Start with 2.5 mg once weekly for 4 weeks.
  • Dose Titration: Increase by 2.5 mg every 4 weeks, up to a maintenance dose of 5 mg, 10 mg, or 15 mg based on response and tolerance.
How to Inject:
  • Timing: Administer once a week, ideally on the same day and time.
  • Injection Sites: Inject into the abdomen, thigh, or outer upper arm. Rotate sites to reduce irritation.
  • Preparation: Use a new needle for each injection. Ensure the pen and medication are not damaged or discolored.
Dosing Schedule:
  • Start with 2.5 mg for 4 weeks, then follow the titration plan for optimal results.
Preparing for Injection:
  • Storage: Store in the refrigerator. Do not use if frozen or discolored.
  • Site Selection: Rotate injection sites each week.
  • Pen Preparation: Wash hands, check label, and only remove the cap when ready to inject.
Troubleshooting:
  • Air Bubbles: Normal in the pen.
  • Post-Injection Leakage: A small drop is normal; apply pressure with gauze.
Important Considerations:
  • Food and Timing: Can be taken with or without food. Consistency in injection timing is key.
  • Long-Term Use: Suitable for long-term use as advised by your healthcare provider.
  • Missed Doses: Take within 4 days. If more than 4 days, skip the dose and resume your schedule.
  • Changing Schedule: Ensure at least 3 days between doses.
Disposal:
  • Dispose of the pen in a sharps bin after use. Always use a new needle.
Monitoring and Adjustments:
  • Monitor your response to Mounjaro and adjust dosage as needed. Consult your provider for any adjustments if you’re taking other diabetes medications.

Mounjaro® Cautionary Guidelines and Contraindications

Mounjaro® may not be suitable for all patients. Specific caution or contraindication applies to the following groups:

Acute Pancreatitis:

Patients with a history of pancreatitis should use Mounjaro with caution, as tirzepatide’s safety has not been well studied in this population. If acute pancreatitis symptoms occur, stop use immediately. Mounjaro is contraindicated in cases of acute pancreatitis.

Hypoglycemia Risk:

When used in combination with insulin or sulphonylureas, tirzepatide can increase the risk of hypoglycemia. Patients should be closely monitored, and dose adjustments to insulin or sulphonylureas may be necessary under the supervision of a healthcare provider.

Gastrointestinal Side Effects:

Side effects such as nausea, vomiting, and diarrhea can lead to dehydration and, in severe cases, acute renal failure. This risk is heightened for elderly patients, who should take preventive measures to maintain hydration and electrolyte balance.

Severe Gastrointestinal Disease:

Mounjaro is contraindicated in patients with severe gastrointestinal diseases, like significant gastroparesis, due to insufficient data on its safety in these conditions.

Diabetic Retinopathy:

Mounjaro is not recommended for patients with certain forms of diabetic retinopathy due to the potential risks involved.

Elderly Patients:

Mounjaro is contraindicated for use in patients over 85 years old.

Drug Interactions:

Tirzepatide can alter the absorption of orally administered medications. Close monitoring is required, especially for drugs with a narrow therapeutic index, to ensure safe and effective treatment.

Special Populations:
  • Pregnancy: Mounjaro should not be used during pregnancy or in women planning to become pregnant.
  • Breastfeeding: Mounjaro is not recommended for breastfeeding women, as the excretion of tirzepatide in breast milk is unknown.

Weight Loss Treatment Comparison

Treatment TypeBrand NameActive Ingredient(s)Mechanism of ActionAdministeredDosage RangeExpected Weight LossCommon Side EffectsManufacturerAdditional Information
InjectionMounjaroTirzepatideCombines GLP-1 receptor agonist and GIP mimetic to regulate blood sugar and appetiteWeeklyStart at 2.5mg, increase to 15mg21% to 22.5%Nausea, stomach upset, diarrhea, constipation, vomitingEli LillyStrong weight loss effect; especially for diabetes management
InjectionWegovySemaglutideGLP-1 receptor agonist that reduces appetite and helps with glucose controlWeeklyStart at 0.25mg, up to 2.4mgAround 15%Nausea, fatigue, gastrointestinal issues, headachesNovo NordiskApproved for weight loss in multiple regions
InjectionSaxendaLiraglutideGLP-1 receptor agonist for appetite regulationDailyStart at 0.6mg, up to 3mg5% to 10%Nausea, low blood sugar, stomach issues, dizzinessNovo NordiskEffective for weight loss and diabetes management
Oral MedicationXenicalOrlistatInhibits fat digestion by blocking enzymesWith mealsOne to three times daily5% to 10%Oily stools, bloating, increased gas, diarrheaHaleonPrevents fat absorption from the diet
Oral MedicationOrlistat (generic)OrlistatSame as Xenical, prevents fat breakdownWith mealsOne to three times daily5% to 10%Similar to Xenical: Gas, fecal urgencyGenericGeneric alternative to Xenical
Oral MedicationAlliOrlistatA lower-dose version of orlistat, blocks fat absorptionWith meals60mg, up to three times daily5%Milder version of Xenical; may cause gastrointestinal discomfortNot specifiedOver-the-counter version of Orlistat
Oral MedicationMysimbaBupropion & NaltrexoneDual-action pill that helps control hunger and cravingsWith meals1-4 tablets daily5% to 10%Dry mouth, headaches, nausea, dizziness, constipationNot specifiedAffects brain pathways to reduce appetite

What Are the Most Common Side Effects of Mounjaro?
When starting Mounjaro for weight loss or diabetes management, common side effects may include diarrhea, nausea, vomiting, constipation, and low blood sugar, especially when combined with certain diabetes medications. These symptoms are usually mild and tend to subside over the first few weeks of treatment.

Can Mounjaro Cause Low Blood Sugar?
Yes, Mounjaro can cause low blood sugar levels, particularly when used alongside insulin or other diabetes medications. Symptoms of low blood sugar include shaking, sweating, dizziness, hunger, and a rapid heartbeat. Notify your doctor if you experience these symptoms.

What Are Other Common Side Effects of Mounjaro?
In addition to diarrhea and nausea, users may experience fast pulse, allergic reactions like eczema or itching, stomach pain, indigestion, bloating, gas, heartburn, fatigue, increased pancreatic enzymes, irritation at the injection site, low blood pressure, dizziness, and hair loss.

Are There Any Uncommon Side Effects of Mounjaro?
Uncommon side effects include gallstones, increased calcitonin levels, weight loss, pain at the injection site, and acute pancreatitis. Severe stomach or back pain may indicate pancreatitis and requires immediate medical attention.

Does Mounjaro Have Any Long-Term Side Effects?
Mounjaro is not known to cause long-term side effects. Most side effects are temporary and improve within a few weeks or after discontinuing the medication.

What Should I Do If I Experience Serious Side Effects from Mounjaro?
Serious side effects such as severe allergic reactions (anaphylaxis) or acute pancreatitis require immediate medical attention. Symptoms like difficulty breathing, swelling of the throat or face, fainting, or severe stomach and back pain should prompt you to seek emergency help.

How Can I Manage Side Effects from Mounjaro?
To manage side effects, follow the prescribed weekly dosage, stay hydrated, consume smaller, non-greasy meals to alleviate nausea, and take anti-diarrheal medication if necessary. Maintaining adequate fiber intake and staying consistent with your injections will also help. Always consult your doctor if side effects persist or become troublesome.

Starter Pack Includes:

  1. Mounjaro Pen 2.5mg (for 4 weeks of use)
  2. 100 x GlucoRx Needles
  3. 100 x Alcohol Swabs
  4. 1 x Sharps Bin

Your Mounjaro order will include only the Mounjaro pen. You will need to separately purchase needles for injections, alcohol pads, and a sharps bin for safe disposal. For detailed instructions on how to use your Mounjaro pen, please refer to the patient information leaflet provided with the product.

Studies suggest that Mounjaro offers greater weight loss than Wegovy. At its highest dose of 15 mg, Mounjaro helps reduce weight by 21% to 22.5%, which is similar to results from bariatric surgery. In contrast, Wegovy typically results in about 15% weight loss. While direct comparisons are limited, Mounjaro appears to outperform Wegovy in weight reduction.

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